Day 1 :
Keynote Forum
R te biesebeke
HNM Foundation, Switzerland
Keynote: The impact of diet on the human microbiome and the brain
Time : 09:35-10:15
Biography:
R te Biesebeke has a PhD from the Top Institute Food and Nutrition, the Wageningen University and Research Centre in the Netherlands, a MSc in Biology from the University of Utrecht, and holds a Biochemistry Engineering (Ing) degree from Saxion Polytechnics (the Netherlands). He started his career in R&D in Molecular Biology in the Unilever Research Laboratory (the Netherlands), followed by Biochemical Research in the Laboratoire de Biochimi of the Ecole Polytechnique (Paris, France) and as PhD fellow in TNO Quality of Life (the Netherlands). He had progressively evolving responsibilities in global operating businesses like Friesland Foods (the Netherlands) and Nestlé (Switzerland). He is former task force member of ILSI Europe (Brussels, Europe) and External Expert of the World Health Organisation (Geneva, Switzerland). As Chief Scientifi c Offi cer and Chairman of the HNM Foundation, he is interested in the Quality of life through the interaction of Human Genome, Nutrition and Microbiology.
Abstract:
Diet strongly affects human health in part by modulating the gut microbiome composition and dependent on the individual genome. The exposure to modifiable risk factors that undermine human health begins in early life and -as it seems- at a much higher frequency in high-income countries compared to Africa and parts of Asia. Recent advances show a growing body of evidence supporting that the human microbial population plays a crucial role in the health of the host. The microbes support to maintain intestinal peristalsis, mucosal integrity, pH balance and immune response. Also, emotional behaviour can be mediated through microbial metabolites, enteric endocrine cell activation, and nerve stimulation. While the enteric nervous system is facilitating in the so-called gut-brain axis, it may contribute to autism spectrum disorders, Alzheimer's disease, Parkinson's disease, depression, and anxiety disorder. As a research concept, the prebiotic fibers and probiotics have gained a lot of attention over the last decennia and this may seem to make micronutrients, fatty acids, carbohydrates and proteins less relevant for the microbiome. In order to provide reliable guidance for human health and wellbeing, the long-term impact of food quality and malnutrition remain the major concerns, while individuality and the microbiome cannot be ignored.
Keynote Forum
Gertrud Angsten
Uppsala University, Sweden
Keynote: Resolution of infantile intestinale pseudo-obstruction in a boy
Time : 10:15-10:55
Biography:
G Angsten has studied Faculty of Medicine in Uppsala University and then at Uppsala University Childrens' Hospital she has worked as a Consultant in Pediatric Surgery up to her retirement. Her PhD work is on fat metabolism, a clinical and experimental study with special reference to newborns. Currently, she works part time as a Pediatricianat Gävle Hospital and her Publications are from Uppsala University. Her research interest are pediatric gastrointestinal disorders, nutrition enteral and parenteral, gastrostomy and jejunostomy.
Abstract:
A term boy with spontaneous passage of meconium exhibited episodes of abdominal distension and diarrhea. Due to failure to thrive and suspicion of Hischsprung’s disease he was referred to our university hospital at five months of age. Rectal biopsies were normal. Laparotomy revealed dilation of the small bowel and colon without any mechanical obstruction. Full thickness bowel biopsies were taken and a loop ileostomy was constructed. Histopathology revealed fibrosing myopathy, Cajal cell hypertrophy, and neuronal degeneration in both the large and small bowel. The small bowel showed mastocytosis without inflammation. A central venous catheter was placed for vascular access, replaced three times and later switched to a subcutaneous venous port. Catheters were locked after use with vancomycin-heparin and later taurolidine. The individually tailored home parenteral nutrition contained unsaturated fatty acid lipids to reduce cholestasis. Initial insufficient growth was improved after correction of partial parenteral nutrition based on a metabolic balance study. The ileostomy was revised once and finally taken down at 11 years of age following one year without parenteral support. At follow-up at 13 years of age he has episodes of moderate abdominal pain has entered puberty and reports a high quality of life.