Dong Li
Jilin University, China
Title: Vitamin A deficiency promotes infl ammation by induction of type 2 cytokines in experimental ovalbumin-induced asthma murine model
Biography
Biography: Dong Li
Abstract
Statement of the Problem: Vitamin A (VA) deficiency is one of the most common malnutrition conditions. Recent reports showed that VA plays an important role in the immune balance, lack of VA could result in enchanted type 2 immune response characterized by increased type 2 cytokines production and type 2 innate lymphoid cells infiltration and activation. Type 2 immune responses plays protective role in anti-infection, but plays pathological role in asthmatic disease.
Methodology & Theoretical Orientation: In order to investigate the role of VA in the asthmatic disease, we used ovalbumin-induced asthma murine model, and observed the pathological changes between mouse received VA-deficient and -sufficient diets. We also measured the type 2 cytokine expressions to reveal the potential mechanism.
Findings: Our results showed that VA deficiency exacerbates ovalbumin-induced lung inflammation via induction of the type 2 cytokine productions.
Conclusion & Significance: VA deficiency, or malnutrition in further extent, may contribute to the increasing prevalence of asthma.
